Renefil
Renefil is a tissue-repair biomaterial containing cross-linked hyaluronic acid (HA), sodium polynucleotide (PN) and lidocaine. Its Korean product information describes temporary correction of moderate to severe nasolabial folds in adults. Filler can help soften shadows caused by hollows.
Renefil is available at QD Clinic in Gangnam, Seoul, Korea.


is this for me
Who it’s for
Even if none of these describes you, we will look again at the consultation.
- How deep the tear trough hollow is, any tendency to puffiness, and whether Renefil’s combined HA and PN formula suits the area
- Renefil is an HA and PN combined formulation; its suitability for the under-eye area is judged by the degree of hollowing and swelling rather than by whether it contains PN. Its purpose of use in Korea concerns nasolabial folds, so the range and limits of use under the eyes are explained separately at the examination. Even though it contains PN, its formulation and properties differ from PN products such as Rejuran, so it is planned separately.
Suitability requires an examination. Skin thickness, health and previous procedures may make a different approach more appropriate.
start with your concern
Before you pick a treatment name, start with the cause of your concern.
Even a treatment with the same name takes on a different role and scope depending on your current structure, the change you want, what you have had before and the recovery time you have.
Where you are now, and where we start
How deep the tear trough hollow is, any tendency to puffiness, and whether Renefil’s combined HA and PN formula suits the area
The change you want, the impression you keep
At consultation, we first look at how deep the tear trough hollow is, any tendency to puffiness, and whether Renefil’s combined HA and PN formula suits the area.
the principle
How it works
Renefil
Under-eye darkness may involve hollows, protruding fat, pigmentation or skin quality. Suitability is judged after checking the product’s approved use, the condition of your eyelids and previous treatments. Whether each product is injected directly under the eyes or used on the surrounding area is decided at the examination.

How it works
What sets it apart
Containing PN does not make Renefil the same as Rejuran. Renefil is a filler made by adding PN and lidocaine to cross-linked hyaluronic acid, and it is planned with both its approved purpose of use and its product properties in mind.
Assessing the change
With HA products, lines, hydration and surface quality are assessed after swelling settles. The area and formulation influence the course and duration. Rather than recommending a fixed number of sessions up front, we decide whether and how often to repeat from your skin condition, the specific product instructions and your response to the first treatment. Allow recovery time before an important event.
the qd standard
The same treatment, never the same plan.
Rather than a fashionable name or a fixed package, we weigh the structure found at examination, safety, recovery and the limits within one plan.
- DIAGNOSIS FIRST
Cause before name
We first separate out the tissue and the function behind your concern.
- LESS, PRECISE
Only as much as needed
Rather than an excessive change, we plan the smallest scope with a clear role.
- HONEST LIMIT
The limits, explained too
We explain the change you can expect, the alternatives, individual differences and the risks.
personal plan
From consultation to follow-up, planned as one flow.
Renefil is a tissue-repair biomaterial containing cross-linked hyaluronic acid (HA), sodium polynucleotide (PN) and lidocaine. Its Korean product information describes temporary correction of moderate to severe nasolabial folds in adults. Filler can help soften shadows caused by hollows.

Start with the concern
Renefil is an HA and PN combined formulation; its suitability for the under-eye area is judged by the degree of hollowing and swelling rather than by whether it contains PN. Its purpose of use in Korea concerns nasolabial folds, so the range and limits of use under the eyes are explained separately at the examination. Even though it contains PN, its formulation and properties differ from PN products such as Rejuran, so it is planned separately.
Understand your product
Containing PN does not make Renefil the same as Rejuran. Renefil is a filler made by adding PN and lidocaine to cross-linked hyaluronic acid, and it is planned with both its approved purpose of use and its product properties in mind.
Plan through recovery
We assess whether what the under-eye area needs is correction of hollowing or improvement of skin texture. After the initial swelling has gone, whether to inject more is decided conservatively by looking at the remaining hollowing and skin response. The injection interval is also set by the remaining hollowing and skin response rather than by expectations of the PN ingredient.
What the procedure is like
- Before your consultation, please note your usual swelling and dry eyes, any previous filler or surgery, and the medicines you take. If you have an important event or departure date, we plan recovery time and how follow-up will be checked as well.
- After appropriate comfort measures and cleansing, the doctor treats the agreed areas.
- We watch for persistent swelling, surface changes and lumps under the eyes. Please also let us know if you have a history of lidocaine allergy. Worsening pain or changes in skin color or vision need immediate medical care.
Appointment length depends on consultation, numbing and treatment extent. Tell us your available time and important plans when booking.
Please read this before treatment
- Avoid strong irritation, overheating and strenuous exercise while the skin settles. Follow your individual instructions for when to resume face washing and makeup.
- Massage and pressure advice differs by product. Follow your clinician’s instructions rather than another product’s routine.
- Persistent swelling, a bluish tint showing through, unevenness and nodules can occur. Rarely, blocked blood vessels can cause serious complications such as skin necrosis, vision damage or blindness, so severe pain, changes in skin color or visual problems need immediate medical care.
Safety & considerations
Possible reactions
- Infection, persistent nodules, unevenness, inflammation or allergic reactions can occur.
- Injections carry rare but serious risks including vascular injury or blockage and tissue damage.
Before treatment
- Tell us about pregnancy or breastfeeding, allergies, immune conditions, medicines, and previous fillers, threads or other procedures.
- Active inflammation or infection at the site needs assessment before treatment is scheduled.
Worsening pain, pale or mottled skin, visual symptoms or breathing difficulty need urgent medical attention. Outcomes and duration vary; a specific result is not guaranteed.
what to expect
What to expect over time
A general guide to how the days and months after treatment usually unfold. Results vary by individual.
Immediately
Initial swelling and fullness are not the final result.
Early recovery
Monitor bruising, swelling and injection marks. Contact the clinic if symptoms worsen or persist.
Next steps
Plan any further session only after assessing the response and recovery.
Sessions & results
We assess whether what the under-eye area needs is correction of hollowing or improvement of skin texture. After the initial swelling has gone, whether to inject more is decided conservatively by looking at the remaining hollowing and skin response. The injection interval is also set by the remaining hollowing and skin response rather than by expectations of the PN ingredient.
before consultation
Before you decide, the questions people always ask
Renefil is a tissue-repair biomaterial containing cross-linked hyaluronic acid (HA), sodium polynucleotide (PN) and lidocaine. Its Korean product information describes temporary correction of moderate to severe nasolabial folds in adults. Filler can help soften shadows caused by hollows. It does not remove pigment itself or protruding fat, and if your under-eye area tends to swell or the skin is very thin, swelling, visible product and unevenness are considered first.
Renefil is an HA and PN combined formulation; its suitability for the under-eye area is judged by the degree of hollowing and swelling rather than by whether it contains PN. Its purpose of use in Korea concerns nasolabial folds, so the range and limits of use under the eyes are explained separately at the examination. Even though it contains PN, its formulation and properties differ from PN products such as Rejuran, so it is planned separately.
We assess whether what the under-eye area needs is correction of hollowing or improvement of skin texture. After the initial swelling has gone, whether to inject more is decided conservatively by looking at the remaining hollowing and skin response. The injection interval is also set by the remaining hollowing and skin response rather than by expectations of the PN ingredient.
We watch for persistent swelling, surface changes and lumps under the eyes. Please also let us know if you have a history of lidocaine allergy. Worsening pain or changes in skin color or vision need immediate medical care.
Look at the examination and the plan rather than the treatment name. First, what the clinic checks before deciding. For this treatment, QD Clinic in Gangnam, Seoul starts by looking at this: “How deep the tear trough hollow is, any tendency to puffiness, and whether Renefil’s combined HA and PN formula suits the area”. Second, whether it explains why it recommends that scope and method, compared with the alternatives. Third, whether it reviews your progress with you when results are expected. Our doctor goes through these three points at consultation before the treatment is decided.
At QD Clinic in Gangnam, Seoul, South Korea. We are at 3F, 502 Gangnam-daero, Gangnam-gu, Seoul (Nonhyeon-dong, Seohee Building), a 4-minute walk from Exit 3 of Nonhyeon or Sinnonhyeon Station. Call +82-2-514-1650 or use the consultation form on this site to book a doctor’s consultation first.



